Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling

MP Brett; AK John; BS Denis; MW Jonathan; PS Donnelly

Journal article

Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling

MP Brett, AK John, BS Denis, MW Jonathan, PS Donnelly

Inorganic Chemistry | AMER CHEMICAL SOC | Published : 2010

DOI: 10.1021/ic902204e

Abstract

New bifunctional derivatives of diacetyl-bis(4-methylthiosemicarbazone) (H2atsm) have been prepared by a selective transamination reaction of a new dissymmetric bis(thiosemicarbazone) precursor H2L1. The new derivatives contain an aliphatic carboxylic acid (H2L2 and H2L3), t-butyl carbamate (H2L 4), or ammonium ion (H2L5) functional group. The new ligands and copper(II) complexes have been characterized by NMR spectroscopy, mass spectrometry, and microanalysis. The complex CuII(L 4) was structurally characterized by X-ray crystallography and shows the metal center to be in an N2S2 distorted square planar coordination geometry. Electrochemical measurements show that the copper(II) complexes u..

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University of Melbourne Researchers

John Karas Author

Jonathan White Author

Paul Donnelly Author

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X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analyt..

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Funding Acknowledgements

We acknowledge the Australian Research Council and the Australian Institute for Nuclear Science and Engineering for financial support of this research, Prof. Henri Tochon-Danguy and Dr. Uwe Ackermann (Centre for PET, Austin Hospital, Melbourne) for provision of radiochernistry facilities, and Prof. Jarnes Carnakaris for our ongoing collaboration.